Discovery of novel metabolic biomarkers in blood serum for diagnosis of Alzheimer's disease

Zhao, Y., Villasante-Tezanos, A., Miranda-Morales, E. G., Pappolla, M. A. & Fang, X., Nov 1 2024, In: Journal of Alzheimer's disease : JAD. 102, 1, p. 237-253 17 p.

A new method has been discovered to detect Alzheimer’s disease using a simple blood test. Blood samples from people with and without Alzheimer’s were analyzed using advanced technology to identify tiny molecules linked to the disease. Artificial intelligence helped pinpoint specific molecules that indicate Alzheimer’s with high accuracy. This breakthrough could lead to an easy, non-invasive way to diagnose the disease early, allowing for faster treatment and better patient care.

Hypercholesterolemia and Alzheimer's Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies

Pappolla, M. A., Refolo, L., Sambamurti, K., Zambon, D. & Duff, K., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S371-S393

High cholesterol in midlife is linked to a higher risk of Alzheimer’s. Studies suggest cholesterol-lowering drugs may help, but clinical trials show mixed results, possibly due to timing or patient selection. Managing cholesterol early, especially for high-risk individuals, could be key, but more research is needed on other treatment options.

Melatonin: Evolving Physiological Understanding and Potential Therapeutic Role in Pain Medicine Including Intervertebral Disc Degeneration

Kaye, A. D., File, C. J., Borne, G. E., Daniel, C. P., Sharma, R., Shekoohi, S. & Pappolla, M. A., Jul 2024, In: Pain physician. 27, 5, p. 273-282 10 p.

Melatonin is known for helping with sleep, but it may also protect the spine from wear and tear. It can reduce swelling, stress on cells, and aging effects in the discs between our backbones. This could lead to new treatments for back pain, helping people feel better without surgery.

Oxidative Stress in Alzheimer's Disease: The Shortcomings of Antioxidant Therapies

Pappolla, M. A., Martins, R. N., Poeggeler, B., Omar, R. A. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S155-S178

Antioxidants are often seen as protective, but treatments using them have not been successful in Alzheimer’s disease. This research highlights challenges such as poor absorption, hidden causes of damage, and overly simple treatment approaches. Understanding these issues could lead to better strategies for slowing the disease’s progression.

Stem Cell Interventions in Neurology: From Bench to Bedside

Pappolla, M. A., Wu, P., Fang, X., Poeggeler, B., Sambamurti, K., Wisniewski, T. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S395-S416

Stem cell therapy is a new approach to treating brain diseases like stroke, Parkinson’s, and Alzheimer’s by helping the body repair damaged cells. While progress has been made, challenges remain in making these treatments safe and effective. In the future, this research could lead to life-changing breakthroughs.

The ABC of Stem Cell Therapies for Neurological Disorders

Pappolla, M. A., Wu, P. & Sambamurti, K., Jan 1 2024, Essentials of Regenerative Medicine in Interventional Pain Management, Second Edition. Springer International Publishing, p. 543-556 14 p.

Stem cell therapy is a promising way to help with brain diseases like stroke, Parkinson’s, and Alzheimer’s by repairing damaged nerves. Although these treatments are still being tested, early results look hopeful. In the future, they could improve brain health, slow aging, and give people better treatment options.

Therapeutic Trials in Alzheimer's Disease: Where Are We Now?

Moreira, P. I., Avila, J., Galimberti, D., Pappolla, M. A., Plascencia-Villa, G., Sorensen, A. A., Zhu, X. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S1-S2

Finding effective treatments for Alzheimer’s disease remains a challenge, but new approaches go beyond traditional drug therapies. Strategies like lifestyle changes, brain stimulation, and repurposed medications are being explored to slow the disease. These efforts offer hope for better treatments that may improve memory and quality of life.

Viral Infections, Are They a Trigger and Risk Factor of Alzheimer’s Disease?

Rippee-Brooks, M. D., Wu, W., Dong, J., Pappolla, M., Fang, X. & Bao, X., Mar 2024, In: Pathogens. 13, 3, 240.

Some viruses, including herpes and COVID-19, may play a role in Alzheimer’s disease by affecting brain cells and the immune system. Understanding this connection could help uncover new ways to prevent or slow the disease. If infections contribute to Alzheimer’s, vaccines or antiviral treatments might reduce the risk.

Changes of tRNA-Derived Fragments by Alzheimer’s Disease in Cerebrospinal Fluid and Blood Serum

Wu, W., Shen, A., Lee, I., Miranda-Morales, E. G., Spratt, H., Pappolla, M. A., Fang, X. & Bao, X., Nov 21 2023, In: Journal of Alzheimer's Disease. 96, 3, p. 1285-1304 20 p.

Nitric Oxide as a Determinant of Human Longevity and Health Span

Poeggeler, B., Singh, S. K., Sambamurti, K. & Pappolla, M. A., Oct 2023, In: International journal of molecular sciences. 24, 19, 14533.

Tryptophan in Nutrition and Health 2.0

Poeggeler, B., Singh, S. K., Sambamurti, K. & Pappolla, M. A., Apr 2023, In: International journal of molecular sciences. 24, 8, 7112.

The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial

Pappolla, M. A., Carare, R. O., Poeggeler, B., Wisniewski, T. & Sambamurti, K., Sep 2022, In: Current Alzheimer Research. 19, 10, p. 689-693 5 p.

Tryptophan in Nutrition and Health

Poeggeler, B., Singh, S. K. & Pappolla, M. A., May 1 2022, In: International journal of molecular sciences. 23, 10, 5455.

Editorial: Pharmacology of L-Arginine and L-Arginine-Rich Food

Poeggeler, B., Robenek, H. & Pappolla, M. A., Aug 3 2021, In: Frontiers in Pharmacology. 12, 743788.

Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease

Pappolla, M. A., Perry, G., Fang, X., Zagorski, M., Sambamurti, K. & Poeggeler, B., Aug 2021, In: Neurobiology of Disease. 156, 105403.

Insulin resistance is associated with central pain in patients with fibromyalgia

Pappolla, M. A., Manchikanti, L., Candido, K. D., Grieg, N., Seffinger, M., Ahmed, F., Fang, X., Andersen, C. & Trescot, A. M., 2021, In: Pain physician. 24, 2, p. 175-184 10 p.

Methodology for evidence synthesis and development of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain

Manchikanti, L., Atluri, S., Boswell, M. V., Calodney, A. K., Diwan, S., Gupta, S., Kaye, A. D., Knezevic, N. N., Candido, K. D., Abd-Elsayed, A., Pappolla, M. A., Racz, G. B., Sachdeva, H., Sanapati, M. R., Shah, S., Singh, V., Soin, A. & Hirsch, J. A., Jan 24 2021, In: Pain physician. 24, p. S1-S26

Is insulin resistance the cause of fibromyalgia? A preliminary report

Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In: PloS one. 14, 5, p. e0216079

Responsible, safe, and effective use of biologics in the management of low back pain: American society of interventional pain physicians (ASIPP) guidelines

Navani, A., Manchikanti, L., Albers, S. L., Latchaw, R. E., Sanapati, J., Kaye, A. D., Atluri, S., Jordan, S., Gupta, A., Cedeno, D., Vallejo, A., Fellows, B., Knezevic, N. N., Pappolla, M., Diwan, S., Trescot, A. M., Soin, A., Kaye, A. M., Aydin, S. M. & Calodney, A. K. & 10 others, , 2019, In: Pain physician. 22, 1S, p. S1-S74

Do regenerative medicine therapies provide long-term relief in chronic low back pain: A systematic review and metaanalysis

Sanapati, J., Manchikanti, L., Atluri, S., Jordan, S., Albers, S. L., Pappolla, M. A., Kaye, A. D., Candido, K. D., Pampati, V. & Hirsch, J. A., Nov 2018, In: Pain physician. 21, 6, p. 515-540 26 p.

Melatonin treatment enhances Aβ lymphatic clearance in a transgenic mouse model of amyloidosis

Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., 2018, In: Current Alzheimer Research. 15, 7, p. 637-642 6 p.

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Oct 1 2015, In: Current Alzheimer Research. 12, 1, p. 32-46 15 p.

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer’s disease

R J Baranello, K L Bharani, V Padmaraju, N Chopra, D K Lahiri, N H Greig, ...
Current Alzheimer Research 12 (1), 32-46

Evidence for lymphatic Aβ clearance in Alzheimer's transgenic mice

Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In: Neurobiology of Disease. 71, p. 215-219 5 p.

Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein

Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In: PloS one. 9, 3, e91531.

Major carboxyl terminal fragments generated by γ-secretase processing of the alzheimer amyloid precursor Are 50 and 51 amino acids long

Pinnix, I., Ghiso, J. A., Pappolla, M. A. & Sambamurti, K., May 2013, In: American Journal of Geriatric Psychiatry. 21, 5, p. 474-483 10 p.

Targets for AD treatment: Conflicting messages from γ-secretase inhibitors

Sambamurti, K., Greig, N. H., Utsuki, T., Barnwell, E. L., Sharma, E., Mazell, C., Bhat, N. R., Kindy, M. S., Lahiri, D. K. & Pappolla, M. A., May 2011, In: Journal of neurochemistry. 117, 3, p. 359-374 16 p.

Amphiphilic amide nitrones: A new class of protective agents acting as modifiers of mitochondrial metabolism

Durand, G., Poeggeler, B., Ortial, S., Polidori, A., Villamena, F. A., Böker, J., Hardeland, R., Pappolla, M. A. & Pucci, B., Jul 8 2010, In: Journal of medicinal chemistry. 53, 13, p. 4849-4861 13 p.

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

Poeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G., Smith, M. A. & Pappolla, M. A., 2010, In: PloS one. 5, 4, e10206.

Differential accumulation of secreted AβPP metabolites in ocular fluids

Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A., Rao, K. J., Pappolla, M. A. & Sambamurti, K., 2010, In: Journal of Alzheimer's Disease. 20, 4, p. 1243-1253 11 p.

Higher incidence of mild cognitive impairment in familial hypercholesterolemia

D Zambón, M Quintana, P Mata, R Alonso, J Benavent, F Cruz-Sánchez, ...
The American journal of medicine 123 (3), 267-274

Leptin and the skin: a new frontier

B Poeggeler, C Schulz, MA Pappolla, E Bodó, S Tiede, H Lehnert, R Paus
Experimental Dermatology 19 (1), 12-18

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

Siedlak, S. L., Casadesus, G., Webber, K. M., Pappolla, M. A., Atwood, C. S., Smith, M. A. & Perry, G., 2009, In: Free Radical Research. 43, 2, p. 156-164 9 p.

Statins, incident Alzheimer disease, change in cognitive function, and neuropathology.

Pappolla, M. A., Dec 9 2008, In: Neurology. 71, 24, p. 2020; author reply 2020-2021

To the Editor

Pappolla, M. A., Dec 9 2008, In: Neurology. 71, 24, p. 2020 1 p.

Value in development of a TAPIR-like mouse monoclonal antibody to Aβ

Sambamurti, K., Pappolla, M. A. & Rao, K. S. J., 2008, In: Journal of Alzheimer's Disease. 14, 2, p. 175-177 3 p.

A unique case of limb-girdle muscular dystrophy type 2A carrying novel compound heterozygous mutations in the human CAPN3 gene

Matsubara, E., Tsuchiya, A., Minami, N., Nishino, I., Pappolla, M. A., Shoji, M. & Abe, K., Jul 2007, In: European Journal of Neurology. 14, 7, p. 819-822 4 p.

Fine-tuning the amphiphilicity: A crucial parameter in the design of potent α-phenyl-N-tert-butylnitrone analogues

Durand, G., Poeggeler, B., Böker, J., Raynal, S., Polidori, A., Pappolla, M. A., Hardeland, R. & Pucci, B., Aug 23 2007, In: Journal of medicinal chemistry. 50, 17, p. 3976-3979 4 p.

Insulysin cleaves the APP cytoplasmic fragment at multiple sites

Venugopal, C., Pappolla, M. A. & Sambamurti, K., Dec 2007, In: Neurochemical Research. 32, 12, p. 2225-2234 10 p.

Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: A new class of protective agents

Ortial, S., Durand, G., Poeggeler, B., Polidori, A., Pappolla, M. A., Böker, J., Hardeland, R. & Pucci, B., May 4 2006, In: Journal of medicinal chemistry. 49, 9, p. 2812-2820 9 p.

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels

J Pacheco-Quinto, EBR de Turco, S DeRosa, A Howard, F Cruz-Sanchez, ...
Neurobiology of disease 22 (3), 651-656

Luteinizing hormone modulates cognition and amyloid-β deposition in Alzheimer APP transgenic mice

G Casadesus, KM Webber, CS Atwood, MA Pappolla, G Perry, RL Bowen, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1762 (4), 447-452

Alzheimer's disease - A dysfunction in cholesterol and lipid metabolism

Lukiw, W. J., Pappolla, M., Pelaez, R. P. & Bazan, N. G., Jun 2005, In: Cellular and Molecular Neurobiology. 25, 3-4, p. 475-483 9 p.

Mitochondrial medicine: Neuroprotection and life extension by the new amphiphilic nitrone LPBNAH acting as a highly potent antioxidant agent

Poeggeler, B., Durand, G., Polidori, A., Pappolla, M. A., Vega-Naredo, I., Coto-Montes, A., Böker, J., Hardeland, R. & Pucci, B., Nov 2005, In: Journal of neurochemistry. 95, 4, p. 962-973 12 p.

Melatonin relieves the neural oxidative burden that contributes to dementias

Reiter, R. J., Tan, D. X. & Pappolla, M. A., 2004, In: Annals of the New York Academy of Sciences. 1035, p. 179-196 18 p.

Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

Petanceska, S. S., DeRosa, S., Sharma, A., Diaz, N., Duff, K., Tint, S. G., Refolo, L. M. & Pappolla, M., 2003, In: Journal of Molecular Neuroscience. 20, 3, p. 395-406 12 p.

Cholesterol, β-amyloid, and Alzheimer's disease

Pappolla, M. A., Petanceska, S., Refolo, L. & Bazan, N. G., 2003, Membrane Lipid Signaling in Aging and Age-Related Disease. Elsevier, p. 163-175 13 p. (Advances in Cell Aging and Gerontology; vol. 12).

Erratum: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease (Journal of Neurochemistry 85 (1101-1108))

Matsubara, E., Bryant-Thomas, T., Pacheco, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz-Sanchez, F., Chyan, Y. J., Smith, M. A., Perry, G., Chain, D. G., Neria, E., Shoji, M., Abe, K., Leone, A., Grundke-Iqbal, I., Wilson, G. L., Ghiso, J., Williams, C. & Refolo, L. M. & 1 others, , Sep 2003, In: Journal of neurochemistry. 86, 5, p. 1312 1 p.

β-secretase processing of the Alzheimer’s amyloid protein precursor (APP)

L Marlow, M Cain, MA Pappolla, K Sambamurti
Journal of Molecular Neuroscience 20, 233-239

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

MA Pappolla, TK Bryant-Thomas, D Herbert, J Pacheco, M Fabra Garcia, ...
Neurology 61 (2), 199-205

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

E Matsubara, T Bryant‐Thomas, J Pacheco Quinto, TL Henry, ...
Journal of Neurochemistry 85 (5), 1101-1108

Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging

YZ Wadghiri, EM Sigurdsson, M Sadowski, JI Elliott, Y Li, H Scholtzova, ...
Magnetic Resonance in Medicine: An Official Journal of the International …

Statin therapy for Alzheimer’s disease: will it work?

SS Petanceska, S DeRosa, V Olm, N Diaz, A Sharma, T Thomas-Bryant, ...
Journal of Molecular Neuroscience 19, 155-161

Development of indole-3-propionic acid (OXIGON™) for alzheimer’s disease

PE Bendheim, B Poeggeler, E Neria, V Ziv, MA Pappolla, DG Chain Journal of molecular neuroscience 19, 213-217

Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Aβ peptide

B Poeggeler, L Miravalle, MG Zagorski, T Wisniewski, YJ Chyan, Y Zhang, ...
Biochemistry 40 (49), 14995-15001

Reviews of evidence regarding interventions to reduce tobacco use and exposure to environmental tobacco smoke

DP Hopkins, PA Briss, CJ Ricard, CG Husten, VG Carande-Kulis, ...
American journal of preventive medicine 20 (2), 16-66

A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease

LM Refolo, MA Pappolla, J LaFrancois, B Malester, SD Schmidt, ...
Neurobiology of disease 8 (5), 890-899

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

LM Refolo, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, ...
Neurobiology of disease 7 (4), 321-331

Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome

A Nunomura, G Perry, MA Pappolla, RP Friedland, K Hirai, S Chiba, ...
Journal of Neuropathology & Experimental Neurology 59 (11), 1011-1017

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

MA Pappolla, YJ Chyan, B Poeggeler, B Frangione, G Wilson, J Ghiso, ...
Journal of neural transmission 107, 203-231

Increased expression but reduced activity of antioxidant enzymes in Alzheimer's disease

RA Omar, YJ Chyan, AC Andorn, B Poeggeler, NK Robakis, MA Pappolla
Journal of Alzheimer's Disease 1 (3), 139-145

RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer’s disease

A Nunomura, G Perry, MA Pappolla, R Wade, K Hirai, S Chiba, MA Smith
Journal of Neuroscience 19 (6), 1959-1964

Potent neuroprotective properties against the Alzheimer β-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid

YJ Chyan, B Poeggeler, RA Omar, DG Chain, B Frangione, J Ghiso, ...
Journal of Biological Chemistry 274 (31), 21937-21942

Amyloid‐β deposition in Alzheimer transgenic mice is associated with oxidative stress

MA Smith, K Hirai, K Hsiao, MA Pappolla, PLR Harris, SL Siedlak, ...
Journal of neurochemistry 70 (5), 2212-2215

Inhibition of Alzheimer β-fibrillogenesis by melatonin

M Pappolla, P Bozner, C Soto, H Shao, NK Robakis, M Zagorski, ...
Journal of Biological Chemistry 273 (13), 7185-7188

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant …

MA Pappolla, YJ Chyan, RA Omar, K Hsiao, G Perry, MA Smith, P Bozner
The American journal of pathology 152 (4), 871

Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide

MA Pappolla, M Sos, RA Omar, RJ Bick, DLM Hickson-Bick, RJ Reiter, ...
Journal of Neuroscience 17 (5), 1683-1690

The amyloid β protein induces oxidative damage of mitochondrial DNA

P Bozner, V Grishko, SP LeDoux, GL Wilson, YC Chyan, MA Pappolla
Journal of Neuropathology & Experimental Neurology 56 (12), 1356-1362

Prophylactic actions of melatonin in oxidative neurotoxicity

RJ Reiter, JM Guerrero, G Escames, MA Pappolla, ...
Annals of the New York Academy of Sciences 825 (1), 70-78

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

MA Pappolla, RA Omar, KS Kim, NK Robakis
The American journal of pathology 140 (3), 621

Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells

K Sambamurti, J Shioi, JP Anderson, MA Pappolla, NK Robakis
Journal of neuroscience research 33 (2), 319-329

Bradykinin induces superoxide anion release from human endothelial cells

JA Holland, KA Pritchard, MA Pappolla, MS Wolin, NJ Rogers, ...
Journal of cellular physiology 143 (1), 21-25

Discovery of novel metabolic biomarkers in blood serum for diagnosis of Alzheimer's disease

Yingxin Zhao, Alejandro Villasante-Tezanos, Ernesto G Miranda-Morales, Miguel A Pappolla, Xiang Fang

Therapeutic Trials in Alzheimer's Disease: Where Are We Now?

Paula I Moreira, Jesus Avila, Daniela Galimberti, Miguel A Pappolla, Germán Plascencia-Villa, Aaron A Sorensen, Xiongwei Zhu, George Perry

Oxidative Stress in Alzheimer's Disease: The Shortcomings of Antioxidant Therapies

Miguel A Pappolla, Ralph N Martins, Burkhard Poeggeler, Rawhi A Omar, George Perry

Hypercholesterolemia and Alzheimer's Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies

Miguel A Pappolla, Lorenzo Refolo, Kumar Sambamurti, Daniel Zambon, Karen Duff

Stem Cell Interventions in Neurology: From Bench to Bedside

Miguel A Pappolla, Ping Wu, Xiang Fang, Burkhard Poeggeler, Kumar Sambamurti, Thomas Wisniewski, George Perry

Melatonin: Evolving Physiological Understanding and Potential Therapeutic Role in Pain Medicine Including Intervertebral Disc Degeneration

Alan D Kaye, Christopher J File, Grant E Borne, Charles P Daniel, Ramaswamy Sharma, Sahar Shekoohi, Miguel A Pappolla

Changes of tRNA-Derived Fragments by Alzheimer's Disease in Cerebrospinal Fluid and Blood Serum

Wenzhe Wu, Audrey Shen, Inhan Lee, Ernesto G Miranda-Morales, Heidi Spratt, Miguel A Pappolla, Xiang Fang, Xiaoyong Bao

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel A Pappolla

Tryptophan in Nutrition and Health 2.0

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel Angelo Pappolla

The Lymphatic System in Neurological Disease and Alzheimer's Disease. A Brief Editorial

Miguel A Pappolla, Roxana O Carare, Burkhand Poeggeler, Thomas Wisniewski, Kumar Sambamurti

Tryptophan in Nutrition and Health

Burkhard Poeggeler, Sandeep Kumar Singh, Miguel A Pappoll